Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission
نویسندگان
چکیده
منابع مشابه
Direct measurement of AMPA receptor desensitization induced by glutamatergic synaptic transmission.
Although almost all ionotropic neurotransmitter receptors undergo desensitization, the onset and recovery of desensitization at a synapse have never been observed directly. We have found changes in postsynaptic AMPA receptor sensitivity in neurons of the chick cochlear nucleus, the nucleus magnocellularis (nMAG), by photolysis of caged glutamate immediately after activation of a single synaptic...
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Excitatory postsynaptic currents in the CA1 region of rat hippocampal slices are mediated primarily by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in response to synaptically released glutamate. Outside-out patches from pyramidal cells in this region have shown that AMPA receptors are desensitized by short (1 ms) pulses of glutamate. We have taken a number of appro...
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Agonist-induced internalization of transmembrane receptors is a widespread biological phenomenon that also may serve as a mechanism for synaptic plasticity. Here we show that the agonist AMPA causes a depression of AMPA receptor (AMPAR) signaling at glutamate synapses in the CA1 region of the hippocampus in slices from developing, but not from mature, rats. This developmentally restricted agoni...
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Compounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or the interaction of GluR2 with NSF caused a gradual reduction in the AMPAR EPSC, while inhibition of endocytosis caused a gradual increase in the AMPAR EPSC. These manipulations had no effect on the NMDAR EPSC but preven...
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meable to calcium and that controls synaptic plasticity. Activation of NMDA receptors leads to the appearance of functional AMPA receptors (“unsilencing”) in previously silent synapses, thereby potentiating synaptic transmission (Malenka and Nicoll, 1999; Malinow et al., Morgan Sheng1,2 and Sang Hyoung Lee2 Department of Neurobiology and Howard Hughes Medical Institute Massachusetts General Hos...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1996
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.16-23-07496.1996